Through games of Sunday, Dec. 12, 2021:
| # | School (No. 1 votes) | W-L | Pts. | Prev. |
| 1 | Yeshiva (13) | 13-0 | 605 | 1 |
| 2 | Randolph-Macon (10) | 8-1 | 603 | 2 |
| 3 | UW-Platteville (2) | 11-0 | 584 | 4 |
| 4 | Illinois Wesleyan | 7-1 | 517 | 3 |
| 5 | UW-Oshkosh | 9-1 | 510 | 6 |
| 6 | Wheaton (Ill.) | 9-1 | 500 | 8 |
| 7 | St. Joseph (Conn.) | 8-0 | 466 | 5 |
| 8 | Marietta | 5-2 | 396 | 10 |
| 9 | UW-La Crosse | 8-2 | 373 | 13 |
| 10 | Roanoke | 6-1 | 371 | 11 |
| 11 | Johns Hopkins | 7-1 | 355 | 12 |
| 12 | Christopher Newport | 7-2 | 341 | 14 |
| 13 | Whitworth | 8-1 | 314 | 15 |
| 14 | Elmhurst | 8-2 | 268 | 7 |
| 15 | Washington U. | 8-1 | 260 | 18 |
| 16 | Mount Union | 7-1 | 221 | 17 |
| 17 | Williams | 9-0 | 204 | 20 |
| 18 | Swarthmore | 7-1 | 189 | 19 |
| 19 | Mary Hardin-Baylor | 5-1 | 173 | 9 |
| 20 | Amherst | 8-0 | 145 | 21 |
| 21 | RPI | 8-0 | 144 | 22 |
| 22 | Heidelberg | 8-1 | 79 | -- |
| 23 | Maryville (Tenn.) | 7-1 | 75 | 24 |
| 24 | DeSales | 10-0 | 71 | 25 |
| 25 | Hardin-Simmons | 9-1 | 68 | -- |
Dropped out: No. 16 Trine; No. 23 Emory.
Others receiving votes: Wesleyan 43; Lynchburg 39; WPI 37; Calvin 32; Trine 29; Case Western Reserve 23; Trinity (Texas) 12; Wooster 11; Oswego 10; Rochester 10; Berry 8; Wartburg 7; Emory 6; Cal Lutheran 5; Brandeis 4; Chapman 4; LeTourneau 4; Nazareth 3; Augsburg 2; Stockton 2; Mary Washington 2.
The D3hoops.com Top 25 is voted on by a panel of 25 coaches, Sports Information Directors and media members from across the country, and is published weekly. Points are awarded on a 25-24-23-22-etc. basis.