Through games of Feb. 26, 2006:
| # | Team | W-L | Pts. | Last Week |
| 1 | Lawrence (21) | 24-0 | 621 | 1 |
| 2 | Hope (4) | 26-2 | 599 | 2 |
| 3 | Wittenberg | 25-3 | 536 | 6 |
| 4 | Amherst | 25-2 | 531 | 5 |
| 5 | Wooster | 25-3 | 514 | 3 |
| 6 | Baldwin-Wallace | 24-4 | 479 | 7 |
| 7 | Virginia Wesleyan | 25-3 | 433 | 8 |
| 8 | Mississippi College | 27-1 | 423 | 10 |
| 9 | York (Pa.) | 24-3 | 411 | 4 |
| 10 | North Central | 22-5 | 332 | 19 |
| 11 | Illinois Wesleyan | 20-6 | 301 | 12 |
| 12 | Calvin | 22-6 | 300 | 13 |
| 13 | Augustana | 21-5 | 284 | 9 |
| 14 | Puget Sound | 21-4 | 282 | 17 |
| 15 | UW-Whitewater | 22-5 | 279 | 20 |
| 16 | St. John Fisher | 24-3 | 272 | 16 |
| 17 | Carroll | 21-4 | 248 | 15 |
| 18 | Lincoln | 23-4 | 242 | 18 |
| 19 | UW-Stout | 21-6 | 239 | 14 |
| 20 | Transylvania | 24-4 | 209 | 21 |
| 21 | Albion | 20-6 | 170 | 11 |
| 22 | Worcester Polytech | 22-3 | 114 | 23 |
| 23 | Carnegie Mellon | 20-5 | 83 | 24 |
| 24 | St. Thomas | 22-5 | 43 | — |
| 25 | Ohio Northern | 21-6 | 41 | 22 |
Dropped out: No. 25 Randolph-Macon
Others receiving votes: Randolph-Macon 34, Elmhurst 21, Whitworth 19, Tufts 12, Occidental 11, Ursinus 10, UW-La Crosse 9, Cortland State 6, Claremont-Mudd-Scripps 5, Carleton 4, Trinity (Texas) 4, Catholic 2, Huntingdon 1, Wilmington 1, Lake Erie 1.
The D3hoops.com Top 25 is voted on by a panel of 25 coaches, Sports Information Directors and media members from across the country, and is published weekly.