Entering the 2005-06 season:
| # | Team | W-L | Pts. | Last Week |
| 1 | Illinois Wesleyan (19) | 21-5 | 616 | 10 |
| 2 | UW-Oshkosh (3) | 19-8 | 539 | 25 |
| 3 | Wooster (1) | 27-3 | 522 | 8 |
| 4 | Puget Sound | 22-4 | 499 | 11 |
| 5 | Amherst | 26-2 | 406 | 6 |
| 6 | York (Pa.) | 28-4 | 405 | 13 |
| 7 | St. John Fisher (1) | 28-1 | 370 | 17 |
| 8 | Albion | 26-4 | 360 | 5 |
| 9 | Hanover (1) | 25-6 | 336 | 7 |
| 10 | Wittenberg | 25-4 | 330 | 9 |
| 11 | Virginia Wesleyan | 24-6 | 292 | — |
| 12 | Ramapo | 24-5 | 274 | 19 |
| 13 | UW-Whitewater | 19-9 | 245 | — |
| 14 | Wartburg | 23-5 | 241 | 23 |
| 15 | Elmhurst | 18-7 | 207 | — |
| 16 | John Carroll | 24-6 | 176 | 12 |
| 17 | Worcester Polytech | 24-4 | 175 | — |
| 18 | Randolph-Macon | 17-10 | 170 | — |
| 19 | Gustavus Adolphus | 22-6 | 168 | 22 |
| 20 | UW-Platteville | 19-7 | 156 | 21 |
| 21 | Mississippi College | 24-6 | 152 | — |
| 22 | Aurora | 23-5 | 133 | 20 |
| 23 | Rochester | 25-5 | 127 | 4 |
| 24 | Calvin | 27-7 | 119 | 2 |
| 25 | Catholic | 20-10 | 115 | — |
Others receiving votes: UW-Stevens Point 113, Springfield 108, Southwestern 93, Ursinus 87, Augustana 82, Transylvania 68, Hope 59, Hampden-Sydney 46, Mary Washington 31, Buena Vista 26, Potsdam State 24, Lawrence 24, Baldwin-Wallace 24, Albright 24, Pomona-Pitzer 22, Hamilton 22, Hobart 21, Maryville (Tenn.) 19, Hardin-Simmons 16, Union 14, King's 13, New Jersey City 11, Carroll 8, Salem State 7, Williams 6, Methodist 6, Trinity (Texas) 5, Scranton 5, UW-Stout 3, St. Thomas 1.
The D3hoops.com Top 25 is voted on by a panel of 25 coaches, Sports Information Directors and media members from across the country, and is published weekly.