Through games of Dec 5, 2021:
| # | School (No. 1 votes) | W-L | Pts. | Prev. |
| 1 | Hope (25) | 7-0 | 625 | 1 |
| 2 | Whitman | 6-0 | 577 | 2 |
| 3 | UW-Eau Claire | 8-0 | 526 | 11 |
| 4 | John Carroll | 5-0 | 501 | 3 |
| 5 | Wartburg | 6-0 | 499 | 5 |
| 6 | Amherst | 7-0 | 477 | 8 |
| 7 | Trine | 7-1 | 467 | 7 |
| 8 | UW-Whitewater | 8-0 | 426 | 12 |
| 9 | Christopher Newport | 9-0 | 420 | 13 |
| 10 | DePauw | 7-0 | 364 | 15 |
| 11 | Bowdoin | 8-1 | 341 | 4 |
| 12 | Simpson | 6-1 | 332 | 14 |
| 13 | Transylvania | 7-0 | 307 | 18 |
| 14 | Hardin-Simmons | 7-1 | 266 | 10 |
| 15 | Tufts | 5-1 | 259 | 16 |
| 16 | Wheaton (Ill.) | 8-1 | 241 | 6 |
| 17 | East Texas Baptist | 6-2 | 236 | 9 |
| 18 | Messiah | 6-1 | 222 | 17 |
| 19 | Scranton | 6-1 | 182 | 19 |
| 20 | Baldwin Wallace | 5-1 | 173 | 21 |
| 21 | New York University | 7-0 | 168 | 24 |
| 22 | Texas-Dallas | 5-1 | 167 | 22 |
| 23 | Gettysburg | 6-1 | 76 | -- |
| 24 | UW-Oshkosh | 7-2 | 64 | 20 |
| 25 | St. John Fisher | 6-0 | 37 | -- |
Correction: One ballot was accidentally cast with North Park, instead of New York University, listed No. 15. That has been corrected in the list above, resulting in NYU moving to 21st and Texas-Dallas to 22nd.
Dropped out: No. 23 Rhodes; No. 25 Catholic
Others receiving votes: Smith 34; Springfield 29; Wisconsin Lutheran 29; Bates 24; St. Benedict 16; Catholic 13; Gustavus Adophus 6; Rhodes 6; Trinity (Texas) 6; St. Lawrence 3; DeSales 2; Roanoke 2; Roger Williams 2
The D3hoops.com Top 25 is voted on by a panel of 25 coaches, Sports Information Directors and media members from across the country, and is published weekly. Points are awarded on a 25-24-23-22-etc. basis.