Through games of Sunday, March 21, 2021. This is likely to be the final women's basketball poll for the 2020-21 season.
| # | School (No. 1 votes) | W-L | Pts. | Prev. |
| 1 | Hope (15) | 16-0 | 225 | 1 |
| 2 | East Texas Baptist | 25-1 | 201 | 2 |
| 3 | Trine | 14-3 | 177 | 3 |
| 4 | Simpson | 12-0 | 174 | 4 |
| 5 | Texas-Dallas | 14-3 | 116 | 5 |
| 6 | Wartburg | 13-3 | 111 | 6 |
| 7 | Wheaton (Ill.) | 11-1 | 110 | 9 |
| 8 | Messiah | 11-0 | 107 | 11 |
| 9 | DePauw | 8-1 | 105 | 7 |
| 10 | Oglethorpe | 7-2 | 93 | 8 |
| 11 | Millsaps | 12-2 | 89 | 10 |
| 12 | Whitman | 9-2 | 50 | 12 |
| 13 | John Carroll | 13-2 | 41 | 13 |
| 14 | DeSales | 9-0 | 33 | -- |
| 15 | Hardin-Simmons | 16-5 | 32 | 14 |
Dropped out: No. 15 Babson
Others receiving votes: UW-Oshkosh 26; Babson 23; N.C. Wesleyan 14; St. Thomas (Minn.) 14; Rhodes 12; Millikin 11; Piedmont 11; UW-Eau Claire 7; Scranton 5; Trinity (Texas) 4; Gustavus Adolphus 3; Lynchburg 3; Maryville (Tenn.) 2; UW-Whitewater 1
The D3hoops.com Top 25 is voted on by a panel of 15 coaches, Sports Information Directors and media members from across the country, and is published weekly. Points are awarded on a 15-14-13-etc. basis.
Because of the changing nature of the pandemic, the number of voters and teams voted for may change from week to week.