Through games of Nov. 28, 2021:
| # | School (No. 1 votes) | W-L | Pts. | Prev. |
| 1 | Hope (25) | 5-0 | 625 | 1 |
| 2 | Whitman | 5-0 | 592 | 4 |
| 3 | John Carroll | 4-0 | 478 | 8 |
| 4 | Bowdoin | 7-0 | 462 | 13 |
| 5 | Wartburg | 4-0 | 455 | 10 |
| 6 | Wheaton (Ill.) | 7-0 | 441 | 11 |
| 7 | Trine | 5-1 | 406 | 3 |
| 8 | Amherst | 5-0 | 393 | 16 |
| 9 | East Texas Baptist | 4-1 | 381 | 2 |
| 10 | Hardin-Simmons | 6-0 | 369 | 14 |
| 11 | UW-Eau Claire | 6-0 | 366 | -- |
| 12 | UW-Whitewater | 6-0 | 361 | 18 |
| 13 | Christopher Newport | 7-0 | 354 | 20 |
| 14 | Simpson | 4-1 | 319 | 6 |
| 15 | DePauw | 6-0 | 315 | 19 |
| 16 | Tufts | 4-1 | 285 | 7 |
| 17 | Messiah | 5-1 | 272 | 5 |
| 18 | Transylvania | 5-0 | 238 | -- |
| 19 | Scranton | 4-1 | 169 | 12 |
| 20 | UW-Oshkosh | 6-1 | 130 | 17 |
| 21 | Baldwin Wallace | 3-1 | 115 | 21 |
| 22 | Texas-Dallas | 2-1 | 103 | 15 |
| 23 | Rhodes | 7-1 | 83 | -- |
| 24 | New York University | 6-0 | 80 | -- |
| 25 | Catholic | 6-0 | 73 | -- |
Others receiving votes: Smith 57; Gettysburg 52; St. John Fisher 41; Wisconsin Lutheran 23; Ithaca 21; Springfield 15; St. Lawrence 14; St. Benedict 10; Trinity (Texas) 8; DeSales 7; Salisbury 3; Babson 2; George Fox 2; Gustavus Adolphus 2; Roanoke 2; SUNY New Paltz 1
The D3hoops.com Top 25 is voted on by a panel of 25 coaches, Sports Information Directors and media members from across the country, and is published weekly. Points are awarded on a 25-24-23-22-etc. basis.