Entering the 2021-22 season:
| # | School (No. 1 votes) | W-L | Pts. | Prev. |
| 1 | Hope (21) | 16-0 | 617 | 1 |
| 2 | East Texas Baptist (3) | 25-1 | 555 | 2 |
| 3 | Trine | 14-3 | 522 | 3 |
| 4 | Whitman | 9-2 | 431 | 12 |
| 5 | Messiah | 11-0 | 429 | 8 |
| 6 | Simpson | 12-0 | 420 | 4 |
| 7 | Tufts | 0-0 | 335 | -- |
| 8 | John Carroll | 13-2 | 320 | 13 |
| 9 | DeSales | 9-0 | 318 | 14 |
| 10 | Wartburg | 13-3 | 315 | 6 |
| 11 | Wheaton (Ill.) | 11-1 | 311 | 7 |
| 12 | Scranton | 7-1 | 286 | -- |
| 13 | Bowdoin | 0-0 | 280 | -- |
| 14 | Hardin-Simmons | 16-5 | 258 | 14 |
| 15 | Texas-Dallas | 14-3 | 254 | 5 |
| 16 | Amherst (1) | 0-0 | 249 | -- |
| 17 | UW-Oshkosh | 9-2 | 247 | -- |
| 18 | UW-Whitewater | 8-3 | 212 | -- |
| 19 | DePauw | 8-1 | 210 | 9 |
| 20 | Christopher Newport | 0-0 | 169 | -- |
| 21 | Baldwin Wallace | 10-5 | 162 | -- |
| 22 | Millikin | 11-3 | 157 | -- |
| 23 | Smith | 0-0 | 121 | -- |
| 24 | George Fox | 5-2 | 108 | -- |
| 25 | Millsaps | 12-2 | 92 | 11 |
Others receiving votes: Piedmont 83; Bethel 79; St. John Fisher 64; Trinity (Texas) 63; Babson 56; N.C. Wesleyan 55; Rhodes 35; Salisbury 34; Chicago 31; Wisconsin Lutheran 29; New York University 28; Oglethorpe 19; Gustavus Adolphus 18; UW-Eau Claire 18; Mary Hardin-Baylor 17; Rhode Island College 17; Ithaca 16; Loras 15; Illinois Wesleyan 11; Lynchburg 10; St. Lawrence 10; Transylvania 10; Central 8; SUNY New Paltz 5; Austin 4; Emory 4; Marymount 4; Johns Hopkins 3; Williams 1.
The D3hoops.com Top 25 is voted on by a panel of 25 coaches, Sports Information Directors and media members from across the country, and is published weekly. Points are awarded on a 25-24-23-22-etc. basis.