Through games of Sunday, March 14, 2021:
| # | School (No. 1 votes) | W-L | Pts. | Prev. |
| 1 | Hope (14) | 16-0 | 224 | 1 |
| 2 | East Texas Baptist (1) | 25-0 | 208 | 2 |
| 3 | Trine | 14-3 | 188 | 3 |
| 4 | Simpson | 12-0 | 161 | 7 |
| 5 | Texas-Dallas | 14-3 | 125 | 8 |
| 6 | Wartburg | 13-3 | 120 | 4 |
| 7 | DePauw | 8-1 | 115 | 9 |
| 8 | Oglethorpe | 7-2 | 108 | 5 |
| 9 | Wheaton (Ill.) | 11-1 | 105 | 10 |
| 10 | Millsaps | 12-2 | 104 | 6 |
| 11 | Messiah | 10-0 | 83 | 12 |
| 12 | Whitman | 9-2 | 45 | 13 |
| 13 | John Carroll | 13-2 | 40 | 14 |
| 14 | Hardin-Simmons | 16-5 | 32 | 11 |
| 15 | Babson | 11-0 | 21 | -- |
Dropped out: No. 15 Maryville (Tenn.)
Others receiving votes: UW-Oshkosh 20; DeSales 18; N.C. Wesleyan 13; St. Thomas (Minn.) 12; UW-Eau Claire 12; Maryville (Tenn.) 10; Piedmont 9; Millikin 8; Rhodes 7; Scranton 5; Gustavus Adolphus 3; UW-Whitewater 2; Lynchburg 1; Trinity (Texas) 1
The D3hoops.com Top 25 is voted on by a panel of 15 coaches, Sports Information Directors and media members from across the country, and is published weekly. Points are awarded on a 15-14-13-etc. basis.
Because of the changing nature of the pandemic, the number of voters and teams voted for may change from week to week.