Through games of Jan. 16, 2022:
| # | School (No. 1 votes) | W-L | Pts. | Prev. |
| 1 | Hope (25) | 14-0 | 625 | 1 |
| 2 | Christopher Newport | 14-0 | 592 | 2 |
| 3 | Transylvania | 12-0 | 555 | 4 |
| 4 | Simpson | 14-1 | 526 | 5 |
| 5 | Trine | 12-2 | 518 | 6 |
| 6 | UW-Whitewater | 15-1 | 481 | 8 |
| 7 | Amherst | 9-1 | 477 | 3 |
| 8 | Whitman | 12-1 | 473 | 7 |
| 9 | New York University | 12-0 | 424 | 10 |
| 10 | Tufts | 11-2 | 380 | 9 |
| 11 | Baldwin Wallace | 10-2 | 335 | 15 |
| 12 | John Carroll | 11-2 | 318 | 12 |
| 13 | Wartburg | 11-2 | 281 | 13 |
| 14 | DePauw | 12-2 | 266 | 16 |
| 15 | Springfield | 14-0 | 223 | 18 |
| 16 | Marietta | 14-1 | 186 | 22 |
| 17 | Hardin-Simmons | 12-2 | 180 | 19 |
| 18 | UW-Eau Claire | 12-4 | 165 | 11 |
| 19 | Bowdoin | 13-3 | 163 | 17 |
| 20 | East Texas Baptist | 10-3 | 135 | 14 |
| 21 | Wisconsin Lutheran | 11-0 | 133 | 23 |
| 22 | Mary Washington | 13-2 | 103 | 20 |
| 23 | UW-Oshkosh | 11-3 | 99 | 21 |
| 24 | Mary Hardin-Baylor | 12-2 | 92 | -- |
| 25 | St. John Fisher | 12-1 | 62 | 25 |
Dropped out: No. 24 Texas-Dallas
Others receiving votes: Bates 56; Texas-Dallas 48; Messiah 42; Trinity (Texas) 35; Catholic 34; Smith 24; Roger Williams 19; Albion 17; WPI 10; Millikin 9; Augsburg 8; Gettysburg 8; Scranton 8; Gustavus Adolphus 7; Redlands 3; UC Santa Cruz 2; Ohio Northern 1; Puget Sound 1; Salisbury 1
The D3hoops.com Top 25 is voted on by a panel of 25 coaches, Sports Information Directors and media members from across the country, and is published weekly. Points are awarded on a 25-24-23-22-etc. basis.