Through games of Jan. 2, 2022:
| # | School (No. 1 votes) | W-L | Pts. | Prev. |
| 1 | Hope (25) | 11-0 | 625 | 1 |
| 2 | Christopher Newport | 13-0 | 570 | 6 |
| 3 | Amherst | 7-0 | 563 | 4 |
| 4 | Transylvania | 10-0 | 514 | 11 |
| 5 | Whitman | 10-1 | 490 | 2 |
| 6 | Simpson | 11-1 | 484 | 10 |
| 7 | Trine | 10-2 | 469 | 7 |
| 8 | UW-Whitewater | 11-1 | 436 | 5 |
| 9 | Tufts | 8-1 | 432 | 14 |
| 10 | UW-Eau Claire | 11-2 | 369 | 8 |
| 11 | New York University | 9-0 | 348 | 15 |
| 12 | John Carroll | 8-2 | 336 | 3 |
| 13 | Bowdoin | 10-2 | 253 | 12 |
| 14 | Wartburg | 8-2 | 241 | 13 |
| 15 | East Texas Baptist | 9-2 | 237 | 17 |
| 16 | DePauw | 11-2 | 234 | 9 |
| 17 | Baldwin Wallace | 7-2 | 210 | 16 |
| 18 | UW-Oshkosh | 11-2 | 174 | 23 |
| 19 | St. John Fisher | 8-0 | 157 | 21 |
| 20 | Springfield | 12-0 | 139 | 25 |
| 21 | Hardin-Simmons | 9-2 | 138 | 20 |
| 22 | Mary Washington | 12-1 | 88 | -- |
| 23 | Texas-Dallas | 6-3 | 82 | 18 |
| 24 | Marietta | 10-1 | 77 | -- |
| 25 | Wisconsin Lutheran | 8-0 | 75 | -- |
Dropped out: No. 19 Gettysburg, No. 22 Bates, No. 24 Wheaton (Ill.)
Others receiving votes: Gettysburg 60; Wheaton (Ill.) 55; Smith 52; Messiah 45; Catholic 29; Mary Hardin-Baylor 29; Trinity (Texas) 29; Roger Williams 20; Bates 18; Scranton 16; UC Santa Cruz 11; Roanoke 6; St. Lawrence 6; Augsburg 5; Puget Sound 2; Drew 1
The D3hoops.com Top 25 is voted on by a panel of 25 coaches, Sports Information Directors and media members from across the country, and is published weekly. Points are awarded on a 25-24-23-22-etc. basis.