Through games of Dec 12, 2021:
| # | School (No. 1 votes) | W-L | Pts. | Prev. |
| 1 | Hope (25) | 9-0 | 625 | 1 |
| 2 | Whitman | 9-0 | 581 | 2 |
| 3 | John Carroll | 7-0 | 527 | 4 |
| 4 | Amherst | 7-0 | 503 | 6 |
| 5 | UW-Whitewater | 8-0 | 495 | 8 |
| 6 | Christopher Newport | 10-0 | 487 | 9 |
| 7 | Trine | 8-1 | 480 | 7 |
| 8 | UW-Eau Claire | 9-1 | 438 | 3 |
| 9 | DePauw | 9-0 | 422 | 10 |
| 10 | Simpson | 7-1 | 402 | 12 |
| 11 | Transylvania | 8-0 | 369 | 13 |
| 12 | Bowdoin | 9-1 | 335 | 11 |
| 13 | Wartburg | 7-1 | 334 | 5 |
| 14 | Tufts | 7-1 | 295 | 15 |
| 15 | New York University | 9-0 | 265 | 22 |
| 16 | Baldwin Wallace | 6-1 | 249 | 20 |
| 17 | East Texas Baptist | 7-2 | 222 | 17 |
| 18 | Texas-Dallas | 5-1 | 205 | 21 |
| 19 | Gettysburg | 7-1 | 180 | 23 |
| 20 | Hardin-Simmons | 8-2 | 105 | 14 |
| 21 | St. John Fisher | 8-0 | 99 | 25 |
| 22 | Bates | 6-1 | 78 | -- |
| 23 | UW-Oshkosh | 7-2 | 76 | 24 |
| 24 | Wheaton (Ill.) | 9-2 | 67 | 16 |
| 25 | Springfield | 10-0 | 58 | -- |
Dropped out: No. 18 Messiah; No. 19 Scranton
Others receiving votes: Messiah 48; Wisconsin Lutheran 38; Smith 35; Scranton 18; Bethany Lutheran 16; Mary Hardin-Baylor 15; Catholic 10; York (Pa.) 10; St. Lawrence 9; Trinity (Texas) 6; Albion 5; Illinois Wesleyan 5; Rhodes 4; DeSales 3; Roanoke 3; Augsburg 1; Mary Washington 1; Roger Williams 1
The D3hoops.com Top 25 is voted on by a panel of 25 coaches, Sports Information Directors and media members from across the country, and is published weekly. Points are awarded on a 25-24-23-22-etc. basis.