The Bombers held the Saints to 16 first-half points, shooting 58.3 percent from the floor while harassing St. Lawrence into missing 19 of 25 shots en route to a 40-16 lead at intermission.
Junior center Devin Shea and sophomore forward Jenn Escobido both scored 12 points to lead the Bombers. Shea added four steals and Escobido contributed three assists.
Freshman forward Samantha Klie scored a career-best 10 points in just 16 minutes off the bench.
Senior guard Jessica Farley collected six assists, five steals and four rebounds.
The Saints were led by senior guard Iris Santoni, who netted seven points.
The Bombers host #4 Rochester Tuesday at 4 p.m.