Through games of Feb. 21, 2010:
| # | Team | W-L | Pts. | Last Week |
| 1 | Amherst (21) | 25-0 | 617 | 1 |
| 2 | Kean (3) | 24-1 | 595 | 2 |
| 3 | Illinois Wesleyan (1) | 24-1 | 571 | 3 |
| 4 | Hope | 24-1 | 555 | 4 |
| 5 | George Fox | 23-2 | 513 | 5 |
| 6 | Washington U. | 20-2 | 490 | 6 |
| 7 | Marymount | 24-1 | 458 | 7 |
| 8 | William Paterson | 22-1 | 448 | 8 |
| 9 | Moravian | 23-2 | 410 | 9 |
| 10 | Carthage | 22-3 | 398 | 10 |
| 11 | Calvin | 22-3 | 368 | 11 |
| 12 | Christopher Newport | 25-0 | 358 | 12 |
| 13 | Puget Sound | 20-3 | 321 | 15 |
| 14 | DePauw | 22-3 | 274 | 17 |
| 15 | Scranton | 20-3 | 258 | 13 |
| 16 | Thomas More | 21-2 | 217 | 14 |
| 17 | Louisiana College | 21-2 | 209 | 19 |
| 18 | Washington and Jefferson | 20-3 | 162 | 22 |
| 19 | Lebanon Valley | 22-3 | 124 | 18 |
| 20 | Messiah | 21-4 | 120 | 16 |
| 21 | Chicago | 19-5 | 113 | 25 |
| 22 | Muhlenberg | 20-4 | 86 | — |
| 23 | Colby | 22-3 | 79 | — |
| 24 | Mary Washington | 20-4 | 59 | 23 |
| 25 | Tufts | 19-4 | 57 | 20 |
Dropped out: No. 21 Farmingdale State; No. 24 Gettysburg.
Others receiving votes: Bowdoin 55, Farmingdale State 51, Ithaca 27, Gettysburg 24, UW-Whitewater 23, St. Norbert 22, Mount Union 20, UW-Stevens Point 18, Howard Payne 6, Rochester 6, Hendrix 5, Mount St. Mary 4, Roanoke 4.
The D3hoops.com Top 25 is voted on by a panel of 25 coaches, Sports Information Directors and media members from across the country, and is published weekly.