Through games of Jan. 22, 2006:
| # | Team | W-L | Pts. | Last Week |
| 1 | Wittenberg (15) | 16-1 | 611 | 1 |
| 2 | Wooster (8) | 16-1 | 606 | 2 |
| 3 | Lawrence (2) | 14-0 | 565 | 5 |
| 4 | Hope | 16-1 | 523 | 4 |
| 5 | Illinois Wesleyan | 14-2 | 513 | 6 |
| 6 | Albion | 14-2 | 504 | 3 |
| 7 | Augustana | 16-1 | 500 | 9 |
| 8 | Baldwin-Wallace | 15-2 | 431 | 10 |
| 9 | York (Pa.) | 14-2 | 360 | 8 |
| 10 | Amherst | 13-2 | 345 | 12 |
| 11 | North Central | 14-2 | 335 | 13 |
| 12 | Puget Sound | 13-3 | 302 | 7 |
| 13 | Wartburg | 14-2 | 293 | 15 |
| 14 | Carnegie Mellon | 14-2 | 283 | 11 |
| 15 | Worcester Polytech | 15-1 | 264 | 14 |
| 16 | Occidental | 13-1 | 254 | 19 |
| 17 | Mississippi College | 14-1 | 236 | 18 |
| 18 | Randolph-Macon | 15-3 | 200 | 17 |
| 19 | UW-Stout | 13-4 | 165 | 21 |
| 20 | Transylvania | 14-3 | 140 | 22 |
| 21 | UW-Oshkosh | 14-4 | 132 | — |
| 22 | St. John Fisher | 12-3 | 102 | 16 |
| 23 | Virginia Wesleyan | 16-3 | 93 | — |
| 24 | Lincoln | 18-4 | 74 | — |
| 25 | Carroll | 12-2 | 40 | — |
Dropped out: No. 20 Hampden-Sydney; No. 23 UW-Whitewater; No. 24 New York University; No. 25 Ohio Northern
Others receiving votes: Trinity (Conn.) 35, Elmhurst 35, Ohio Northern 33, UW-Whitewater 26, Rochester 24, Calvin 21, Widener 13, UW-Stevens Point 13, New York University 13, Bluffton 13, Maryville (Tenn.) 8, Washington U. 7, Catholic 4, Loras 3, Bates 3, Cortland State 2, William Paterson 1.
The D3hoops.com Top 25 is voted on by a panel of 25 coaches, Sports Information Directors and media members from across the country, and is published weekly.