Through games of Jan. 16, 2022:
| # | School (No. 1 votes) | W-L | Pts. | Prev. |
| 1 | Randolph-Macon (19) | 12-1 | 618 | 1 |
| 2 | UW-Platteville (6) | 16-0 | 606 | 2 |
| 3 | Illinois Wesleyan | 12-2 | 564 | 3 |
| 4 | Washington U. | 12-1 | 547 | 4 |
| 5 | UW-Oshkosh | 13-2 | 484 | 6 |
| 6 | Marietta | 12-2 | 483 | 8 |
| 7 | Yeshiva | 14-1 | 469 | 5 |
| 8 | St. Joseph (Conn.) | 10-0 | 449 | 7 |
| 9 | Christopher Newport | 15-2 | 437 | 9 |
| 10 | UW-La Crosse | 13-2 | 409 | 11 |
| 11 | Swarthmore | 14-1 | 354 | 16 |
| 12 | Elmhurst | 11-3 | 296 | 13 |
| 13 | Johns Hopkins | 11-2 | 290 | 12 |
| 14 | Wheaton (Ill.) | 13-3 | 253 | 10 |
| 15 | Wesleyan | 15-1 | 243 | 21 |
| 16 | Maryville (Tenn.) | 12-1 | 241 | 18 |
| 17 | Mount Union | 11-2 | 219 | 14 |
| 18 | Whitworth | 11-2 | 169 | 20 |
| 19 | WPI | 12-1 | 162 | 23 |
| 20 | Williams | 12-1 | 158 | 22 |
| 21 | Heidelberg | 11-2 | 142 | 19 |
| 22 | Mary Hardin-Baylor | 12-2 | 94 | 17 |
| 23 | RPI | 11-1 | 92 | 24 |
| 24 | Case Western Reserve | 12-1 | 76 | -- |
| 25 | Oswego State | 13-1 | 52 | -- |
Dropped out: No. 15 Roanoke; No. 25 Emory
Others receiving votes: Augsburg 36; Emory 33; Middlebury 29; Nazareth 28; DeSales 25; LeTourneau 19; Roanoke 11; Berry 11; Lynchburg 7; Tufts 6; Mass-Dartmouth 4; Rochester 4; Eastern 2; Wabash 2; Clark 1.
The D3hoops.com Top 25 is voted on by a panel of 25 coaches, Sports Information Directors and media members from across the country, and is published weekly. Points are awarded on a 25-24-23-22-etc. basis.